Anti-Idiotype Antibody Development Service

KMD Bioscience has extensive experiences developing custom anti-idiotypic antibody (anti-ID Abs). Our team is capable of producing high specificity and affinity of anti-idiotypic antibody to support investigators’ research, like preclinical research, clinical trials and biosimilar products.

 

Custom Antibody Production-Anti-Idiotype Antibody Generation Service

An antibody possesses several complementarity determining regions (CDRs). Anti-idiotypes are typically raised against the CDR regions (idiotype) of the drug antibody. Therapeutic antibody drugs (ADC drugs) are typically coupled to drugs using CDR1 or CDR3 domains which isolated from the variable regions of antibodies and used as a cancer immunotherapy tool.

Our team offers a complete protocol of Anti-idiotype antibody production to meet our clients’ individual requirements by using our own Phage Display Platform. Combined with our proprietary and innovative phage display technology and gene synthesis technology, hybridoma cell lines and peripheral blood lymphocyte samples, we are able to construct a natural, a semi-synthetic or a fully synthetic phage display library for our investigators (independent clones ~1013, effective clones ~109-10). We can provide our customers high specificity & affinity of anti-idiotypic antibodies by panning those libraries. Moreover, we use PCR technology cloning the fragment of screened high affinity of anti-idiotypic antibody to our phagemid expression system. The system we own allows the high expression of anti-idiotypic antibodies in phage, prokaryotic and mammalian expression systems.

 

Applications:

* Antibody Drugs Immunogenicity Study

* Preclinical studies of therapeutic antibodies

* Clinical development of anti-drug antibodies

* Controls in Ligand Neutralization and Antibody Blocking Assays

*Antibody drug pharmacokinetics (PK) and pharmacodynamics (PD) study: Used for high-throughput detection of specific antibody drugs in the free, bound, or total blood.

 

Service Highlights:

*Full traceable support system, GMP/GLP level

*High-throughput antibody screening platform

*High specificity and binding affinity

 

*Full service integration