KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
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Through the efforts of the research team, KMD Bioscience has built up a mature antibody production platform backed by well-established antibody engineering technology. Polyclonal antibody can recognize multiple epitopes on the same antigen and has a superior affinity and quicker binding capability than monoclonal antibodies. KMD Bioscience has a good reputation in antibody production, including monoclonal and polyclonal antibody production, which has withstood the test of time. With our advanced antibody production technology, our scientists are confident in producing antibodies with high specificity and affinity. A variety of species are available and customization is supported. |
Compared with mammalian IgG antibodies, chicken IgY has higher specificity, affinity, and a lower risk of cross-reactivity. These advantages make IgY antibodies valuable in laboratory scientific research and diagnostic fields. KMD Bioscience provides customizable chicken polyclonal antibody production services. Immunogen and immunization protocols can be tailored to generate chicken polyclonal antibodies, and our experts can provide a full protocol including antigen design, sera collection, antibody purification, titer determination and related services to customers.
Chicken Polyclonal Antibody Production:
The main component of chicken polyclonals is IgY. Chicken IgY is present in both serum and egg yolk. In addition, IgG and IgY share the same overall structure, general structure of the IgY molecule is the same as that of IgG with 2 heavy (H_) chains with a molecular mass of 67–70 kDa each and two light (L) chains with the molecular mass of 25 kDa each. This feature prevents many molecules, especially from the host's immune system from binding, which can in some cases make IgY a good choice for in vivo studies. Indeed, IgY does not bind with proteins of the complement system, mammalian rheumatoid factors, Fc-receptors or with proteins A or G. Therefore, the background signal or false response in very sensitive immunological applications such as immunohistochemistry is dramatically reduced.
Service Process:
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Service Highlights:
--Rich experience in polyclonal antibody development
--High affinity and specificity
--High productivity and special suitability
--IgY does not bind to cell surface Fc receptor
--Moderate cost: collecting eggs with the synthesized antibodies in egg yolk
--Good alternative for highly conserved mammalian proteins
--One-stop services, including antigen production, antibody development, antibody purification, titer determination and related services
Comparison of Different Species:
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Species |
Characteristic |
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Rats |
* Little antigen required
* Ideal hosts for polyclonal antibody productions
* These hosts only provide small amounts of whole antisera |
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* Good for most projects
* Produce strong immune reactions against most antigens in a relatively short period of time
* The raw anti-sera can be used directly in assays |
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* Good for large amount of polyclonal antibody production
* Serum can be used directly in initial assays |
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* Antibodies compose two identical heavy chains
* Good for antibody humanization
* Have the ability to withstand elevated temperatures and a wide pH range |
How to Order?
If you have any questions regarding our services or products, please feel free to contact us by E-mail: info@kmdbioscience.com or Tel: +86-400-621-6806;
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com
