KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
| Catalog Number | KMH1132 |
|---|---|
| Product Name | Recombinant Human GADD45B Protein, His Tag |
| Product Description | Recombinant Human GADD45B Protein, His Tag (KMH1132) contains the human GADD45B(Met1-Arg160) was fused with the N-terminal His Tag and expressed in E. coli. |
| Molecular Name | GADD45B |
| Uniprot ID | O75293 |
| Alias | MYD118, GADD45BETA, growth arrest and DNA damage inducible beta |
| Protein Family | Other protein |
| Size | 50ug, 100ug |
| Species | Human |
| Host | E. coli |
| Molecular Weight | 17.6 kDa |
| Purity | ≥90% as determined by SDS-PAGE |
| Endotoxin | Please contact our customer service for more information. |
| Cross-Reactivity | No cross-reactivity with other antigens or proteins. |
| Buffer | PBS |
| Purification | Affinity Purification |
| Background | GADD45B is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45B reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. GADD45B is involved in the regulation of growth and apoptosis. GADD45b takes part during chondrocyte terminal differentiation and mediates MMP-13 gene expression. GADD45 in B cells is induced by CD4 via a mechanism that involves NF-kappa B and that induction suppresses Fas-mediated killing. GADD45b is down-regulated in most cases of hepatocellular carcinoma (HCC), and is a molecular marker in the diagnosis of HCC and as a possible therapeutic target. |
| Storage | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com
