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Determining Seroconversion to Peste Des Petits Ruminants Virus
2023-10-12
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Peste des petits ruminants (PPR) is an infectious viral disease, primarily of small ruminants such as sheep and goats, but is also known to infect a wide range of wild and domestic Artiodactyls inc...
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Assessing the Generation of Tissue Resident Memory T Cells by Vaccines
2023-09-28
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Vaccines have been a hugely successful public health intervention, virtually eliminating many once common diseases of childhood. However, they have had less success in controlling endemic pathogens...
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Antiviral Neutralizing Antibodies: From in Vitro to in Vivo Activity
2023-09-25
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Neutralizing antibodies (nAbs) are being increasingly used as passive antiviral reagents in prophylactic and therapeutic modalities and to guide viral vaccine design.
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The Unique Properties of IgG4 and its Roles in Health and Disease
2023-09-21
Read(208)
IgG4 is the least abundant subclass of IgG in human serum and has unique functional features. IgG4 is largely unable to activate antibody-dependent immune effector responses and, furthermore, under...
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Cell Death by Phagocytosis
2023-09-18
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Cells can die as a consequence of being phagocytosed by other cells — a form of cell death that has been called phagotrophy, cell cannibalism, programmed cell removal and primary phagocytosis. How...
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Native Mass Spectrometry Combined with Enzymatic Dissection Unravels Glycoform Heterogeneity of Biopharmaceuticals
2023-09-07
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Robust manufacturing processes resulting in consistent glycosylation are critical for the efficacy and safety of biopharmaceuticals.
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Trogocytosis Challenges the Cellular Specificity of Lineage Markers and Monoclonal Antibodies
2023-08-31
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The transfer of surface molecules between cells by trogocytosis challenges the concept of cell type-unique surface markers and indicates that monoclonal antibodies used for therapeutic purposes may...
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CLASH:Large-scale Engineering System for the Discovery of Better CAR T Cells
2023-08-29
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Adoptive immune cell therapy has been effective in treating haematological cancers. However, some patients experience disease relapse, which may be attributed to insufficient persistence of T cells...
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Commensal Fungi Support Granulocyte Development
2023-08-24
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Laboratory mice kept in specific-pathogen-free (SPF) conditions are routinely used to dissect the immune system, but they lack the microbial exposures that normally shape the immune system.
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Lactation-associated Macrophages
2023-08-22
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Macrophages contribute to mammary gland remodelling during development, pregnancy and involution postlactation, but less is known about their role during lactation.
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Cell Signaling in Cancer: From Mechanisms to Therapy
2023-08-17
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Since 2016, this conference has brought together investigators focused on basic mechanisms of cancer development, translational research, and early-phase clinical research.
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Image-seq: Image-guided Cell Isolation for Spatially Resolved Transcriptomic Analysis
2023-08-15
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Spatial transcriptomics encompasses a set of technologies capable of resolving spatial differences in gene expression with subcellular resolution.
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The Role of Platelets in Immune-mediated Inflammatory Diseases
2023-08-12
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Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and uncontrolled inflammation and thrombosis, both of which are responsible for organ damage, morbidity and death.
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How to Predict the Specificity of T Cells?
2023-08-07
Read(252)
Recent advances in machine learning and experimental biology have offered breakthrough solutions to problems such as protein structure prediction that were long thought to be intractable.
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The Role of Galectins in Immunity and Infection
2023-08-03
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The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by a wide variety of cells and bind to galactose-containing glycans.
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Laws and Regulations
2022-11-24
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Honorary qualification and registered trademark of the company
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Mirusviruses Link Herpesviruses to Giant Viruses
2023-04-21
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DNA viruses have a major influence on the ecology and evolution of cellular organisms, but their overall diversity and evolutionary trajectories remain elusive. Here we carried out a phylogeny-guid...
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The roles of extracellular vesicles in the immune system
2023-04-17
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The twenty-first century has witnessed major developments in the field of extracellular vesicle (EV) research, including significant steps towards defining standard criteria for the separation and ...
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Role of Unfolded Protein
2023-03-03
Read(367)
Initiating and maintaining optimal immune responses requires high levels of protein synthesis, folding, modification and trafficking in leukocytes, which are processes orchestrated by the endoplasm...
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The biology of TREM receptors
2023-02-13
Read(426)
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages.