KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
| Catalog Number | KMH1156 |
|---|---|
| Product Name | Recombinant Human GDNF Protein, His Tag |
| Product Description | Recombinant Human GDNF Protein, His Tag (KMH1156) contains the human GDNF(Ser78-Ile211) was fused with the C-terminal His Tag and expressed in E. coli. |
| Molecular Name | GDNF |
| Uniprot ID | P39905 |
| Alias | ATF, ATF1, ATF2, HSCR3, HFB1 GDNF, glial cell derived neurotrophic factor |
| Protein Family | Other protein |
| Size | 50ug, 100ug |
| Species | Human |
| Host | E. coli |
| Molecular Weight | 14.74 kDa |
| Purity | ≥90% as determined by SDS-PAGE |
| Endotoxin | Please contact our customer service for more information. |
| Cross-Reactivity | No cross-reactivity with other antigens or proteins. |
| Buffer | PBS |
| Purification | Affinity Purification |
| Background | GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFR α(α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional rat GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 11) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration. |
| Storage | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com
