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Recombinant Human GFRA2 C-fc Protein, His & Fc Tag

Product Information
Catalog Number KMH1161
Product Name Recombinant Human GFRA2 C-fc Protein, His & Fc Tag
Product Description Recombinant Human GFRA2 C-fc Protein, His & Fc Tag (KMH1161) contains the human GFRA2(Ser22-Ser441) was fused with the C-terminal His Fc Tag and expressed in Mammalian cells.
Molecular Name GFRA2
Uniprot ID O00451
Alias NTNRA, RETL2, TRNR2, GDNFRB, NRTNR ALPHA, GDNF family receptor alpha 2
Protein Family Other protein
Size 50ug, 100ug
Species Human
Host Mammalian cells
Molecular Weight 71.2 kDa
Purity ≥90% as determined by SDS-PAGE
Endotoxin < 1.0 EU per ug of the protein as determined by the LAL method.
Cross-Reactivity No cross-reactivity with other antigens or proteins.
Buffer PBS
Purification Affinity Purification
Background Glial cell line-derived neurotrophic factor family receptor alpha-2, also known as GFRA2, is the cognate co-receptor for the neurotrophic factor neurturin that is selectively expressed by isolectin B(4) (IB 4)-binding nociceptive sensory neurons. GFRA2 is required for the development of the myenteric nerve plexus and is an excellent candidate gene for Hirschsprung disease (HSCR). GFRalpha2 signaling is also needed for development of the parasympathetic islet innervation that is critical for vagally induced hormone secretion.
Storage Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.