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Catalog Number | KMH1161 |
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Product Name | Recombinant Human GFRA2 C-fc Protein, His & Fc Tag |
Product Description | Recombinant Human GFRA2 C-fc Protein, His & Fc Tag (KMH1161) contains the human GFRA2(Ser22-Ser441) was fused with the C-terminal His Fc Tag and expressed in Mammalian cells. |
Molecular Name | GFRA2 |
Uniprot ID | O00451 |
Alias | NTNRA, RETL2, TRNR2, GDNFRB, NRTNR ALPHA, GDNF family receptor alpha 2 |
Protein Family | Other protein |
Size | 50ug, 100ug |
Species | Human |
Host | Mammalian cells |
Molecular Weight | 71.2 kDa |
Purity | ≥90% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per ug of the protein as determined by the LAL method. |
Cross-Reactivity | No cross-reactivity with other antigens or proteins. |
Buffer | PBS |
Purification | Affinity Purification |
Background | Glial cell line-derived neurotrophic factor family receptor alpha-2, also known as GFRA2, is the cognate co-receptor for the neurotrophic factor neurturin that is selectively expressed by isolectin B(4) (IB 4)-binding nociceptive sensory neurons. GFRA2 is required for the development of the myenteric nerve plexus and is an excellent candidate gene for Hirschsprung disease (HSCR). GFRalpha2 signaling is also needed for development of the parasympathetic islet innervation that is critical for vagally induced hormone secretion. |
Storage | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |