KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
| Catalog Number | KMH1744 |
|---|---|
| Product Name | Recombinant Human SPINK1 Protein, His Tag |
| Product Description | Recombinant Human SPINK1 Protein, His Tag (KMH1744) contains the human SPINK1(Asp24-Cys79) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
| Molecular Name | SPINK1 |
| Uniprot ID | P00995 |
| Alias | TCP, PCTT, PSTI, TATI, Spink3, serine peptidase inhibitor Kazal type 1 |
| Protein Family | Other protein |
| Size | 50ug, 100ug |
| Species | Human |
| Host | Mammalian cells |
| Molecular Weight | 6.16 kDa |
| Purity | ≥90% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per ug of the protein as determined by the LAL method. |
| Cross-Reactivity | No cross-reactivity with other antigens or proteins. |
| Buffer | PBS |
| Purification | Affinity Purification |
| Background | Serine Protease Inhibitor KazalType 1 (SPINK1) is a trypsin inhibitor that prevent the trypsincatalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). Recombinant SPINK1 protein (rSPINK1) stimulated cell proliferation in benign RWPE as well as cancerous prostate cells. The research result indicated that the potential of SPINK1 as an extracellular therapeutic target in prostate cancer. In contrast, knockdown of SPINK1 in 22RV1 cells inhibited cell proliferation, cell invasion, and tumor growth in xenograft assays. |
| Storage | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com
