KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
| Catalog Number | KMH365 |
|---|---|
| Product Name | Recombinant Human CD201/PROCR Protein, His Tag |
| Product Description | Recombinant Human CD201/PROCR Protein, His Tag (KMH365) contains the human PROCR(Met1-Thr209) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
| Molecular Name | PROCR |
| Uniprot ID | Q9UNN8 |
| Alias | CCCA, EPCR, CCD41, protein C receptor |
| Protein Family | CD molecule |
| Size | 50ug, 100ug |
| Species | Human |
| Host | Mammalian cells |
| Molecular Weight | 22.99 kDa |
| Purity | ≥90% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per ug of the protein as determined by the LAL method. |
| Cross-Reactivity | No cross-reactivity with other antigens or proteins. |
| Buffer | PBS |
| Purification | Affinity Purification |
| Background | Endothelial Protein C Receptor (EPCR) is a Vitamin Kdependent Serine Protease that plays a major role in blood coagulation. Binding of Protein C to EPCR leads to the proteolytic activation of PAR1 (ProteaseActivated Receptor 1) on endothelial cells and subsequent upregulation of Protein Cinduced genes. EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology. EPCR plays an important role in augmenting Protein C activation by the ThrombinThrombomodulin complex and in regulating blood coagulation and inflammation. EPCR is found primarily on endothelial cells. Deletion of EPCR function results in embryonic death, at least in part due to placental thrombosis. |
| Storage | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com
