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Catalog Number | KMH896 |
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Product Name | Recombinant Human CNDP1 Protein, His Tag |
Product Description | Recombinant Human CNDP1 Protein, His Tag (KMH896) contains the human CNDP1(Pro28-His507) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
Molecular Name | CNDP1 |
Uniprot ID | Q96KN2 |
Alias | CN1, CPGL2, HsT2308, carnosine dipeptidase 1 |
Protein Family | Other protein |
Size | 50ug, 100ug |
Species | Human |
Host | Mammalian cells |
Molecular Weight | 52.91 kDa |
Purity | ≥90% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per ug of the protein as determined by the LAL method. |
Cross-Reactivity | No cross-reactivity with other antigens or proteins. |
Buffer | PBS |
Purification | Affinity Purification |
Background | CNDP1, also known as beta-Ala-His dipeptidase, belongs to the peptidase M2A family. The shortest allelic form (CNDP1 Mannheim) was more common in the absence of nephropathy and was associated with lower serum carnosinase levels. Carnosine inhibited the increased production of fibronectin and collagen type VI in podocytes and the increased production of TGF-beta in mesangial cells. Diabetic patients with the CNDP1 Mannheim variant are less susceptible for nephropathy. Carnosine protects against the adverse effects of high glucose levels on renal cells. |
Storage | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |