KMD Bioscience Co., Ltd.
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| Catalog Number | KMP2574 |
|---|---|
| Product Name | Human TGFBR2 Protein, His Tag |
| Product Description | The Human TGFBR2 Protein(KMP2574) is produced in Insect Cells. The target gene encoding the human TGFBR2 (NP_003233.4) (Met1-Gln166) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | TGFBR2 |
| Alias | Human TGFBR2 Protein, His Tag, TGFBR2 |
| Molecular Weight | 17.8 kDa |
| Species | Human |
| Size | 50ug, 100ug, 200ug |
| Host | Insect Cells |
| Purity | >90% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | 20mM PBS, 150mM NaCl, 10% Glycerol, 0.5mM TCEP, pH7.0 |
| Purification | Affinity purification |
| Background | TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilized by a network of six intra strand disulfide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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