KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
| Catalog Number | KMP2798 |
|---|---|
| Product Name | Human NOTCH2 Protein, His Tag |
| Product Description | The Human NOTCH2 Protein(KMP2798) is produced in Insect Cells. The target gene encoding the human NOTCH2 (NP_001186930.1) (Met1-Gln530) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | NOTCH2 |
| Alias | Human NOTCH2 Protein, His Tag, NOTCH2 |
| Molecular Weight | 55.5 kDa |
| Species | Human |
| Size | 50ug, 100ug, 200ug |
| Host | Insect Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | 20mM Tris, 500mM NaCl, 10% Glycerol, pH8.0 |
| Purification | Affinity purification |
| Background | NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of developmental processes by controlling cell fate decisions. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced expression is associated with a less differentiated, more aggressive phenotype, and reduced overall survival. NOTCH2 has also been shown to have pro-apoptotic and growth-suppressive effects in thyroid carcinoma, and carcinoid tumors. NOTCH2 acts as an oncogene that promotes bladder cancer growth and metastasis through EMT, cell-cycle progression, and maintenance of stemness. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com
