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| Catalog Number | KMP2814 |
|---|---|
| Product Name | Human CD8 alpha Protein, His Tag |
| Product Description | The Human CD8 alpha Protein(KMP2814) is produced in CHO Cells. The target gene encoding the extracellular domain of human CD8A (NP_001759.3) (Met1-Asp182) is expressed with a C-terminal polyhistidine tag. |
| Molecular Name | CD8 alpha |
| Alias | Human CD8 alpha Protein, His Tag, CD8 alpha |
| Molecular Weight | 19 kDa |
| Species | Human |
| Size | 50ug, 100ug, 200ug |
| Host | CHO Cells |
| Purity | >90% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Background | T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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