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| Catalog Number | KMP2933 |
|---|---|
| Product Name | Human L-selectin Protein, His Tag |
| Product Description | The Human L-selectin Protein(KMP2933) is produced in CHO Cells. The target gene encoding the human SELL (NP_000646.3) (Met1-Asn332) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | L-selectin |
| Alias | Human L-selectin Protein, His Tag, L-selectin |
| Molecular Weight | 35.6 kDa |
| Species | Human |
| Size | 50ug, 100ug, 200ug |
| Host | CHO Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | 50mM Tris, 100mM NaCl, pH8.0 |
| Purification | Affinity purification |
| Background | L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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