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Catalog Number | KMP2961 |
---|---|
Product Name | Human LRP6 Protein, hFc Tag |
Product Description | The Human LRP6 Protein(KMP2961) is produced in HEK293 Cells. The target gene encoding the Human LRP6 (O75581) (Met1-Pro630) is expressed with the Fc region of human IgG1 at the C-terminus. |
Molecular Name | LRP6 |
Alias | Human LRP6 Protein, hFc Tag, LRP6 |
Molecular Weight | 95.69 kDa |
Species | Human |
Size | 50ug, 100ug, 200ug |
Host | HEK293 Cells |
Purity | >90% as determined by SDS-PAGE |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Buffer | PBS, pH7.4 |
Purification | Affinity purification |
Background | Lipoprotein receptor-related protein 6 (LRP6) binds to Wnt ligands to transduce signal by stabilization of beta-catenin, which has been involved in the regulation of embryonic development and metabolism. Low density lipoprotein (LDL) receptor-related protein-6 (LRP6) is an important co-receptor of Wnt pathway, which plays a predominant role in the development and progression of colorectal cancer. This gene, termed LDL receptor-related protein 6 (LRP6), encodes a transmembrane protein that has 71% identity and is structurally similar to the protein encoded by LRP5, a proposed candidate gene for type 1 diabetes located on human chromosome 11q13. LRP6 maps to human chromosome 12p11-p13. |
Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Note | This product is for research use only. |