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Catalog Number | KMP2966 |
---|---|
Product Name | Human GBA Protein, His Tag |
Product Description | The Human GBA Protein(KMP2966) is produced in HEK293 Cells. The target gene encoding the human GBA (NP_000148.2) (Ala40-Gln536) is expressed with a polyhistidine tag at the C-terminus. |
Molecular Name | GBA |
Alias | Human GBA Protein, His Tag, GBA |
Molecular Weight | 57 kDa |
Species | Human |
Size | 50ug, 100ug, 200ug |
Host | HEK293 Cells |
Purity | >95% as determined by SDS-PAGE |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Buffer | PBS, pH7.4 |
Purification | Affinity purification |
Background | Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are attractive therapeutic targets for treating mutant GBA-associated PD. |
Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Note | This product is for research use only. |