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Catalog Number | KMP3064 |
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Product Name | Human UNC5A Protein, hFc Tag |
Product Description | The Human UNC5A Protein(KMP3064) is produced in HEK293 Cells. The target gene encoding the human UNC5A (NP_588610.2) (Met1-Tyr306) is expressed with the Fc region of human IgG1 at the C-terminus. |
Molecular Name | UNC5A |
Alias | Human UNC5A Protein, hFc Tag, UNC5A |
Molecular Weight | 58.3 kDa |
Species | Human |
Size | 50ug, 100ug, 200ug |
Host | HEK293 Cells |
Purity | >95% as determined by SDS-PAGE |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Buffer | PBS, pH7.4 |
Purification | Affinity purification |
Background | The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cumulatively downregulated by the unfolding protein response (UPR) at the transcriptional level in vitro and at the translational level both in vitro and in vivo. Also, UNC5A is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis. |
Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Note | This product is for research use only. |