KMD Bioscience Co., Ltd.
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Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
| Catalog Number | KMP3147 |
|---|---|
| Product Name | Human BCCIP Protein |
| Product Description | The Human BCCIP Protein(KMP3147) is produced in Insect Cells. The target gene encoding the human BCCIP (AAH09771.1) (Met1-Val314) is expressed with two additional amino acids (Gly & Pro) at the N-terminus. |
| Molecular Name | BCCIP |
| Alias | Human BCCIP Protein, BCCIP |
| Molecular Weight | 36.2 kDa |
| Species | Human |
| Size | 50ug, 100ug, 200ug |
| Host | Insect Cells |
| Purity | >85% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | 20mM Tris, 500mM NaCl, 3mM DTT, 10% Glycerol, pH7.4 |
| Purification | Affinity purification |
| Background | BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations may overcome the progression suppression imposed by BCCIP deficiency through a synthetic viability mechanism. Knockdown of YY1 inhibited the binding of BCCIP itself at BCCIP promoter region proximal to TSS, demonstrating that transcriptional regulation of the YY1 on BCCIP can be modulated by BCCIP itself in a YY1-dependent fashion. BCCIP (BRCA2 and CDKN1A interacting protein) plays a critical role in maintaining the critical functions of p53 in tumor suppression and response to therapy. Celecoxib affects the functions of p53 and inhibits the recovery from the irradiation-induced injury by up-regulating the expression of BCCIP, and subsequently regulates the expressions of genes such as p21 and Cyclin B1 to enhance the radiosensitivity of HCT116 cells in a COX-2 independent manner. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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Email：info@kmdbioscience.com
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