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Catalog Number | KMP3405 |
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Product Name | Human TL1A Protein, mFc Tag |
Product Description | The Human TL1A Protein(KMP3405) is produced in HEK293 Cells. The target gene encoding the human TNFSF15 (NP_005109.2) (Leu72-Leu251) is expressed with the Fc region of mouse IgG1 at the N-terminus. |
Molecular Name | TL1A |
Alias | Human TL1A Protein, mFc Tag, TL1A |
Molecular Weight | 47.1 kDa |
Species | Human |
Size | 50ug, 100ug, 200ug |
Host | HEK293 Cells |
Purity | >90% as determined by SDS-PAGE |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Buffer | PBS, pH7.4 |
Purification | Affinity purification |
Background | TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. |
Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Note | This product is for research use only. |