KMD Bioscience Co., Ltd.
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| Catalog Number | KMP3992 |
|---|---|
| Product Name | Mouse LIGHT Protein, His Tag |
| Product Description | The Mouse LIGHT Protein(KMP3992) is produced in Insect Cells. A DNA sequence encoding the Mouse TNFSF14 (NP_062291.1) (Asp72-Val239) is expressed with a polyhistidine tag at the N-terminus. |
| Molecular Name | LIGHT |
| Alias | LIGHT Protein, Mouse LIGHT Protein, His Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Mouse |
| Host | Insect Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | 20mM Tris, 500mM NaCl, 10% Gly, pH8.0 |
| Purification | Affinity purification |
| Molecular Weight | 20.5 kDa |
| Background | LIGHT, also known as TNFSF14 or CD258, is a newly identified member of the TNF superfamily (TNFSF14) that is expressed by activated T lymphocytes, monocytes, granulocytes, spleen cells, and immature dendritic cells. TNFSF14/LIGHT/CD258 is a type II transmembrane protein that is known to bind 2 membrane-bound TNFSF signaling receptors: HVEM, which is predominantly expressed by T cells, and lymphotoxin β receptor (LTβR), which is expressed by stromal cells and nonlymphoid hematopoietic cells. TNFSF14/LIGHT/CD258 also binds to a soluble non-signaling receptor, decoy receptor 3 (DcR3), which can modulate the function of LIGHT in vivo. TNFSF14/LIGHT/CD258 can also costimulate T cell responses via HVEM, which is constitutively expressed in most lymphocyte subpopulations, including CD4+ and CD8+ T cells. In addition, TNFSF14/LIGHT/CD258 has been shown to suppress tumor formation in vivo and to induce tumor cell apoptosis via the up-regulation of intercellular adhesion molecule 1 and an increased lymphocyte adhesion to cancer cells. Thus, TNFSF14/LIGHT/CD258 is being actively investigated as a possible basis for cancer treatment. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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Email：info@kmdbioscience.com
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