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| Catalog Number | KMP4059 |
|---|---|
| Product Name | Mouse IL-9 Protein, His Tag |
| Product Description | The Mouse IL-9 Protein(KMP4059) is produced in Insect Cells. A DNA sequence encoding the Mouse IL9 (NP_032399.1) (Met1-Pro144) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | IL-9 |
| Alias | IL-9 Protein, Mouse IL-9 Protein, His Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Mouse |
| Host | Insect Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | 50mM Tris, 150mM NaCl, 10% Glycerol, pH8.0 |
| Purification | Affinity purification |
| Molecular Weight | 15.6 kDa |
| Background | Interleukin 9, also known as IL-9, is a cytokine (cell signaling molecule) belonging to the group of interleukins. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL-9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. IL-9 is a key molecule that affects the differentiation of TH17 cells and Treg function. IL-9 predominantly produced by TH17 cells synergizes with TGF-β1 to differentiate naive CD4+ T cells into TH17 cells, while IL-9 secretion by TH17 cells is regulated by IL-23. Interestingly, IL-9 enhances the suppressive functions of FoxP3+ CD4+ Treg cells in vitro, and the absence of IL-9 signaling weakens the suppressive activity of nTregs in vivo, leading to an increase in effector cells and worsening of experimental autoimmune encephalomyelitis. The mechanism of IL-9 effects on TH17 and Tregs is through activation of STAT3 and STAT5 signaling. Our findings highlight the role of IL-9 as a regulator of pathogenic versus protective mechanisms of immune responses. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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