Mouse NPC2 Protein, His Tag

Product Information

Catalog Number	KMP4074
Product Name	Mouse NPC2 Protein, His Tag
Product Description	The Mouse NPC2 Protein(KMP4074) is produced in HEK293 Cells. A DNA sequence encoding the Mouse Npc2 (NP_075898.1) (Met1-Ser149) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	NPC2
Alias	NPC2 Protein, Mouse NPC2 Protein, His Tag
Size	50ug, 100ug, 200ug
Species	Mouse
Host	HEK293 Cells
Purity	>95% as determined by SDS-PAGE
Endotoxin	<1.0 EU/ug determined by the LAL method
Buffer	PBS, pH7.4
Purification	Affinity purification
Molecular Weight	15.9 kDa
Background	Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation.
Storage	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Note	This product is for research use only.

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