KMD Bioscience Co., Ltd.
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| Catalog Number | KMP4154 |
|---|---|
| Product Name | Mouse C-MPL Protein, His Tag |
| Product Description | The Mouse C-MPL Protein(KMP4154) is produced in HEK293 Cells. A DNA sequence encoding the Mouse MPL (Q08351-1) (Met1-Trp482) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | C-MPL |
| Alias | C-MPL Protein, Mouse C-MPL Protein, His Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Mouse |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Molecular Weight | 52.64 kDa |
| Background | CD11, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number of cells of hematopoietic origin. C-MPL is homologous with members of the hematopoietic receptor superfamily. The presence of anti-sense oligodeoxynucleotides of C-Mpl inhibited megakaryocyte colony formation. Thrombopoietin is the ligand for C-Mpl. It was shown to be the major regulator of megakaryocytopoiesis and platelet formation. Defects in c-MPL are a cause of congenital amegakaryocytic thrombocytopenia which is a disease characterized by isolated thrombocytopenia and Megakaryocytopenia with no physical anomalies. Defects in c-MPL also cause thrombocythemia type 2 and myelofibrosis with myeloid metaplasia. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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