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Catalog Number | KMP4192 |
---|---|
Product Name | Rat CXCL10 Protein, His Tag |
Product Description | The Rat CXCL10 Protein(KMP4192) is produced in Yeast. A DNA sequence encoding the rat CXCL10 (NP_620789.1) (Ile22-Pro98) is expressed with a polyhistidine tag at the C-terminus. |
Molecular Name | CXCL10 |
Alias | CXCL10 Protein, Rat CXCL10 Protein, His Tag |
Size | 50ug, 100ug, 200ug |
Species | Rat |
Host | Yeast |
Purity | >95% as determined by SDS-PAGE |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Buffer | PBS, pH7.4 |
Purification | Affinity purification |
Molecular Weight | 10 kDa |
Background | (C-X-C motif) ligand (CXCL)10 (CXCL10) belongs to the ELR(-) CXC subfamily chemokine. CXCL10/IP-10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor coupled to G proteins. CXCL10/IP-10 and its receptor, CXCR3, appear to contribute to the pathogenesis of many autoimmune diseases, organ specific (such as type 1 diabetes, autoimmune thyroiditis, Graves' disease and ophthalmopathy), or systemic (such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, mixed cryoglobulinemia, Sjögren syndrome, or systemic sclerosis). CXCL10/IP-10 is secreted by several cell types including endothelial cells, fibroblasts, keratinocytes, thyrocytes, preadipocytes, etc. Determination of high level of CXCL10/IP-10 in peripheral fluids is therefore a marker of host immune response. |
Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Note | This product is for research use only. |