KMD Bioscience Co., Ltd.
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Email：info@kmdbioscience.com
| Catalog Number | KMP4216 |
|---|---|
| Product Name | Rat CDH6 Protein, His Tag |
| Product Description | The Rat CDH6 Protein(KMP4216) is produced in HEK293 Cells. A DNA sequence encoding the rat CDH6 (EDL82944.1) (Met1-Ala615) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | CDH6 |
| Alias | CDH6 Protein, Rat CDH6 Protein, His Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Rat |
| Host | HEK293 Cells |
| Purity | >80% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Molecular Weight | 67.9 kDa |
| Background | Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morpho regulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progression in a number of adenocarcinomas. Cadherin-6 (CDH6), also known as K-cadherin (KCAD), is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains an 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 is highly expressed in brain, cerebellum, and kidney, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected lung, pancreas, and gastric mucosa. Additionally, it is specifically expressed in the proximal tubule of normal kidneys and in renal cell cancer. Thus, Cadherin-6 is a new prognostic factor for renal cancer. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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