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| Catalog Number | KMP4286 |
|---|---|
| Product Name | Rhesus Betacellulin Protein, hFc Tag |
| Product Description | The Rhesus Betacellulin Protein(KMP4286) is produced in HEK293 Cells. A DNA sequence encoding the Rhesus BTC (XP_001101880.3) (Met1-Tyr111) is expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | Betacellulin |
| Alias | Betacellulin Protein, Rhesus Betacellulin Protein, hFc Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Rhesus |
| Host | HEK293 Cells |
| Purity | >85% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Molecular Weight | 36 kDa |
| Background | Betacellulin(BTC) is a member of the epidermal growth factor (EGF) family. These soluble proteins are ligands for one or more of the four receptor tyrosine kinases encoded by the ErbB gene family (ErbB-1/epidermal growth factor receptor (EGFR), neu/ErbB-2/HER2, ErbB-3/HER3 and ErbB-4/HER4). Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. This protein is a ligand for the EGF receptor. BTC is a polymer of about 62-111 amino acid residues. Secondary Structure: 6% helical (1 helices; 3 residues)36% beta sheet (5 strands; 18 residues). BTC was originally identified as a growth-promoting factor in mouse pancreatic β-cell carcinoma cell line and has since been identified in humans. It plays a role in the growth and development of the neonate and/or mammary gland function. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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