KMD Bioscience Co., Ltd.
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Email：info@kmdbioscience.com
| Catalog Number | KMP4289 |
|---|---|
| Product Name | Rhesus TGF beta 2 Protein, His Tag |
| Product Description | The Rhesus TGF beta 2 Protein(KMP4289) is produced in HEK293 Cells. A DNA sequence encoding the Rhesus TGFB2 (NP_001253447.1) (Met1-Ser414) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | TGF beta 2 |
| Alias | TGF beta 2 Protein, Rhesus TGF beta 2 Protein, His Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Rhesus |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Molecular Weight | 47 kDa |
| Background | TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Silencing Smad2 and Smad3 efficiently blocked the effect of TGF beta 2 on cell proliferation, migration, and extracellular matrix production. TGF beta 2 activation of MEKK3/ERK1/2/5 signaling modulates Has2 expression and hyaluronan (HA) production leading to the induction of epithelial to mesenchymal transformation (EMT) events. Besides, the upregulation of the TGF beta 2 level is a common pathological feature of Alzheimer's disease (AD) brains and suggests that it may be closely linked to the development of neuronal death related to AD. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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