KMD Bioscience Co., Ltd.
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| Catalog Number | KMP4327 |
|---|---|
| Product Name | Rhesus CDCP1 Protein, His Tag |
| Product Description | The Rhesus CDCP1 Protein(KMP4327) is produced in HEK293 Cells. A DNA sequence encoding the Rhesus CDCP1 (XP_001114659.1) (Met1-Thr667) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | CDCP1 |
| Alias | CDCP1 Protein, Rhesus CDCP1 Protein, His Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Rhesus |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Molecular Weight | 73.4 kDa |
| Background | CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and immature hematopoietic stem cell subsets. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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Email：info@kmdbioscience.com
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