KMD Bioscience Co., Ltd.
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| Catalog Number | KMP4355 |
|---|---|
| Product Name | Rhesus CD33 Protein, His Tag |
| Product Description | The Rhesus CD33 Protein(KMP4355) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus/Rhesus CD33 (EHH59833.1/EHH30318.1) (Met1-Gly248) is expressed with a polyhistidine tag at the C-terminus. Cynomolgus and Rhesus CD33 sequences are identical. |
| Molecular Name | CD33 |
| Alias | CD33 Protein, Rhesus CD33 Protein, His Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Rhesus |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Molecular Weight | 27.3 kDa |
| Background | Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33/Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33/Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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