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| Catalog Number | KMP4411 |
|---|---|
| Product Name | E. coli LON PROTEASE Protein, His Tag |
| Product Description | The E. coli LON PROTEASE Protein, His Tag(KMP4411) is produced in E. coli. A DNA sequence encoding E.coil Lon (P0A9M0) (Met1-Lys784) was expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | LON PROTEASE |
| Alias | LON PROTEASE, LON PROTEASE Protein |
| Molecular Weight | 88.3 kDa |
| Species | E. coli |
| Host | E. coli |
| Size | 50ug, 100ug, 200ug |
| Purification | Affinity purification |
| Purity | ＞90% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, 10% Glycerol, pH7.4 |
| Background | Lon protease, an ATP-dependent mitochondrial protease, is important in mitochondrial protein maintenance. Lon protease is a multifunctional enzyme, and its functions include the degradation of damaged proteins and naturally short-lived proteins, ATPase and chaperone-like activities, as well as DNA binding. Lon protease plays a major role in the protein quality control system in mammalian cell mitochondria. It is present in the mitochondrial matrix and degrades oxidized and misfolded proteins, thereby protecting the cell from various extracellular stresses, including oxidative stress. The intellectual disability-associated and thalidomide-binding protein cereblon (CRBN) contains a large, highly conserved Lon domain. The Lon ATP-dependent protease plays an important role in regulating many biological processes in bacteria. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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