KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
| Catalog Number | KMP4547 |
|---|---|
| Product Name | H5N1 (A/chicken/VietNam/NCVD-016/2008) HA Protein, His Tag |
| Product Description | The H5N1 (A/chicken/VietNam/NCVD-016/2008) HA Protein(KMP4547) is produced in Insect Cells. A DNA sequence encoding the Influenza A virus (A/chicken/VietNam/NCVD-016/2008(H5N1))hemagglutinin(ACO07033.1) (Met1-Gln532) was expressed with a C-terminal polyhistidine tag. |
| Molecular Name | H5N1 HA |
| Molecular Weight | 60.2 kDa |
| Alias | H5N1 HA, Hemagglutinin Protein, H5N1 HA Protein |
| Size | 50ug, 100ug, 200ug |
| Species | H5N1 |
| Host | Insect Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <0.01 EU/ug determined by the LAL method |
| Buffer | 50mM His, 0.5M NaCl, pH6.2 |
| Purification | Affinity purification |
| Background | Papillomaviruses are highly species-specific and can cause squamous epithelial and fibroepithelial tumors in their hosts. Human papillomaviruses (HPVs) are associated with benign and malignant hyperproliferation of cells, with a wide variety of clinical manifestations ranging from condyloma acuminatum to cervical carcinoma. HPV infection is the most common sexually transmitted disease. More than 4 HPV types so far identified are known to infect the genital tract. Genital HPVs are divided into `low risk' HPVs such as HPV 6 and 11 and ‘high risk’ HPV types such as 16, 18, 31, 33, 35, 39, 45 and 52, 58 which are responsible for more than 95% of HPV-induced cervical cancer. Vaccination against these high-risk types seems to be the most feasible prevention for cervical cancer. Indeed, clinical trials have shown prophylactic HPV vaccines to be effective against HPV infection, cervical intraepithelial neoplasia (CIN), and genital warts, but protection is type-specific and the currently developed vaccines target only a few types. These vaccines are based on papillomavirus-like particles (VLPs) composed of the major capsid protein, L1. The L1 protein self assembles into VLPs when expressed at high levels in eukaryotic or insect cells. VLPs are composed of 36 copies of L1 protein organized into 72 pentamers, so-called capsomeres, to form particles that are immunologically indistinguishable from native virions. Experimentally induced VLP antisera are mostly type-specific for neutralization. Minor cross-neutralization has been observed only between closely related HPV types, e.g. HPV6 and 11, HPV18 and 45, or HPV16 and 31. Structure analysis has revealed the presence of several hypervariable loops on the outer surface of the capsid. With a few exceptions, all HPV-neutralizing monoclonal antibodies analyzed so far are type-specific and recognize conformational epitopes within surface-exposed hypervariable loops of the major capsid protein L1. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
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