KMD Bioscience Co., Ltd.
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| Catalog Number | KMP4801 |
|---|---|
| Product Name | HIV (group M, subtype A, strain 92UG037.1) gp140 Protein, Fc Tag |
| Product Description | The HIV (group M, subtype A, strain 92UG037.1) gp140 Protein(KMP4801) is produced in HEK293 Cells. A DNA sequence encoding the HIV-1 envelope glycoprotein gp160 (AAC97548.1) extracellular domain (Leu33-Lys659), termed as gp140, was expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | HIV gp140 |
| Molecular Weight | 97.4 kDa |
| Alias | HIV gp140, Envelope Protein gp140, HIV gp140 Protein |
| Size | 50ug, 100ug, 200ug |
| Species | HIV |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Background | The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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