KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
| Catalog Number | MAV102 |
|---|---|
| Product Name | Recombinant Human anti-COVID-19/SARS-CoV-2 S1 RBD Monoclonal Antibody |
| Clonity | Recombinant mAb |
| Alias | SARS-CoV-2 RBD antibody, 2019-nCoV, Coronavirus |
| Product Description | The product is specific for SARS-CoV-2 Spike Protein S1 subunit(Cat.#: COV362) and its RBD domain(Cat.#: COV363), and can inhibit the interaction between SARS-CoV-2 Spike Protein RBD and ACE2. Cat#. MAV101 and Cat#.MAV102 are antibody pair which is verified for ELISA. |
| Size | 100ul,500ul,1ml |
| Clone Number | 7H6 |
| Isotype | IgG1 |
| Species | COVID-19 |
| Host | Human |
| Applications | ELISA, Colloidal Gold, POCT, Netrolization, Standard Positive Control |
| Endotoxin | <0.1EU/ug determided by LAL method. |
| Biological Activity | IC50 = 32 ng/mL using using ELISA method |
| Buffer | 0.01M PBS, pH 7.4 |
| Cross-Reactivity | React with SARS-CoV-2(COVID-19) S1-RBD protein. Do not react with other SARS-CoV-2 subunits. |
| Background | A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-19. A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor—angiotensin-converting enzyme 2 (ACE2)—in humans. Researchers determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2. In comparison with the SARS-CoV RBD, an ACE2-binding ridge in SARS-CoV-2 RBD has a more compact conformation; moreover, several residue changes in the SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD–ACE2 interface. These structural features of SARS-CoV-2 RBD increase its ACE2-binding affinity. Additionally, we show that RaTG13, a bat coronavirus that is closely related to SARS-CoV-2, also uses human ACE2 as its receptor. |
| Storage | This product can be stored at 2℃-8℃ for one month. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | Shipped on ice packs. |
| Note | This product is used for research use only. Not for human or diagnostic use. |
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com
