KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
CD275 (Gene ID:23308), also known as ICOSLG (inducible T-cell co-stimulatory molecule ligand), is a gene located on human chromosome 21. It is a member of the B7 family of co-stimulatory molecules and is essential for immune system function. CD275 is a glycosylated transmembrane structural protein. The interaction between ICOSLG and its receptor, ICOS, is essential for T-cell activation, proliferation, differentiation, and cytokine production, as well as antibody secretion from B-cells during the secondary immune response. This response plays a key role in immune responses, including immunopathogenesis associated with infection, hypersensitivity reactions, autoimmune diseases, transplantation immunity, and tumor immunity.
ICOSLG acts as a prominent co-stimulatory factor in endothelium-mediated T cell activation and plays an important role in the reactivation of effector/memory T cells on the endothelium, regulating the entry of immune cells into inflamed tissues. The gene is expressed in both non-lymphoid and lymphoid tissues. While its expression is usually low in initial B cells and monocytes, it can be rapidly upregulated in response to IFN-γ, TNF-α, or LPS stimulation. This upregulation mainly regulates the secretion of Th2 cytokines, which influences the type of immune response.
KMD Bioscience is an innovative biotechnology company, dedicated to providing high-quality ICOSLG/CD275 protein, ICOSLG/CD275 antibody and other high-quality targeting products to research institutes, universities and companies. Adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality ICOSLG/CD275 related products and promoting the continuous innovation and development in the field of biotechnology.
The featured target ICOSLG/CD275 protein products launched by KMD Bioscience:
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CAT# |
Products Name |
Specise |
Host |
Size |
Inquiry |
|
KMPH3259 |
Human |
HEK293 Cells |
100ug, 200ug |
||
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KMPH3260 |
Human |
HEK293 Cells |
100ug, 200ug |
||
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MOP1185 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
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MOP1186 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5915 |
Human |
HEK293 Cells |
100ug, 200ug |
||
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KMH424 |
Human |
Mammalian cells |
50ug, 100ug |
||
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KMH512 |
Human |
Mammalian cells |
50ug, 100ug |
||
|
KMH1239 |
Human |
Mammalian cells |
50ug, 100ug |
The featured target ICOSLG/CD275 antibody product launched by KMD Bioscience:
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CAT# |
Products Name |
Specise |
Host |
Appliance |
Size |
Inquiry |
|
PA15392 |
Human |
Rabbit |
WB, IHC |
50ul, 100ul |
Other advantageous products from KMD Bioscience:
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com