SIRPA Target

CD172a belongs to the immunoglobulin superfamily of membrane proteins, also known as SIRPα (Gene ID:140885), PTPNS1, MFR, p84, BIT, and SHPS-1. It exhibits predominant expression in myeloid cells, such as macrophages. The protein encoded by the human CD172a gene contains 504 amino acids with a molecular weight of 54.97 kDa. The structure of the protein is complex, with the intracellular region containing four immunoreceptor tyrosine inhibitory motifs and the extracellular region containing three Ig-like regions. The extracellular Ig-like regions contain two IgSF structural domains and an amino-terminal structural domain, which is capable of binding to CD47, a signaling molecule that prevents phagocytosis by macrophages. Interaction between CD172a on the surface of macrophages and CD47 signals macrophages to inhibit their phagocytosis. Therefore, blocking the binding of CD172a to CD47 can promote phagocytosis of tumor cells by macrophages, thus achieving the purpose of anti-tumor.

KMD Bioscience is an innovative biotechnology company dedicated to providing high-quality SIRPA protein, SIRPA antibody and other high-quality target products for research institutions, universities and companies. Adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality SIRPA-related products and promoting the continuous innovation and development in the field of biotechnology.

The featured target SIRPA protein products launched by KMD Bioscience:

CAT#	Product Name	Species	Host	Size	Inquiry
KMPH3288	Human SIRPA Protein, His Tag	Human	HEK293 Cells	50ug, 100ug	Inquiry
MOP1761	Mouse SIRPA Protein, Fc Tag	Mouse	HEK293 Cells	50ug, 100ug	Inquiry
MOP1762	Mouse SIRPA Protein, His Tag	Mouse	HEK293 Cells	50ug, 100ug	Inquiry
PR304	Rat SIRPA Protein, His Tag	Rat	HEK293 Cells	50ug, 100ug	Inquiry
KMPH5899	Human SIRPA Protein, Fc Tag	Human	HEK293 Cells	50ug, 100ug	Inquiry
KMPH5900	Human SIRPA Protein, Fc Tag	Human	HEK293 Cells	50ug, 100ug	Inquiry
KMPH5901	Human SIRPA Protein, Fc Tag	Human	HEK293 Cells	50ug, 100ug	Inquiry
KMPH5902	Human SIRPA Protein, His Tag	Human	HEK293 Cells	50ug, 100ug	Inquiry
KMH355	Recombinant Human CD172A/SIRPA Protein, His Tag	Human	Mammalian cells	50ug, 100ug	Inquiry
KMH1723	Recombinant Human SIRPA Protein, Fc Tag	Human	Mammalian cells	50ug, 100ug	Inquiry
KMH1724	Recombinant Human SIRPA Protein, His Tag	Human	Mammalian cells	50ug, 100ug	Inquiry
MOP2276	Recombinant Mouse Sirpa Protein, Fc Tag	Mouse	Mammalian cells	50ug, 100ug	Inquiry
MOP2277	Recombinant Mouse Sirpa/CD172a Protein, Fc Tag	Mouse	Mammalian cells	50ug, 100ug	Inquiry

The featured target SIRPA antibody product launched by KMD Bioscience:

CAT#	Product Name	Species	Host	Appliance	Size	Inquiry
PA16838	Rabbit Anti-Human SIRPA pAb	Human	Rabbit	WB, IF	50ul, 100ul	Inquiry

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SIRPA Target