KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
CD73 (Gene ID:4907), also known as extracellular-5'-nucleotidase, is a cell surface enzyme encoded by the NT5E gene, which plays an important role in purine metabolism, immunomodulation, and tissue protection. CD73 is a glycosylphosphatidylinositol (GPI)-anchored protein that catalyzes the conversion of extracellular adenosine monophosphate (AMP) to adenosine, a nucleoside known for its potent immunosuppressive and tissue-protective properties. CD73 is widely expressed in a variety of tissues, including the endothelium, immune cells, and the tumor microenvironment. CD73 is a pivotal enzyme in the adenosine pathway, responsible for dephosphorylates AMP generated through ATP catabolism into adenosine. Adenosine acts as a signaling molecule with immunosuppressive properties on immune cells, reducing inflammation and preventing excessive immune responses. Adenosine produced by CD73 plays an important role in immune system by inhibiting immune cell activation through its receptors (A1, A2A, A2B, and A3), suppressing the function of T cells, B cells, natural killer (NK) cells, and macrophages. This mechanism aids in maintaining immune tolerance and prevents autoimmune reactions. Furthermore, adenosine derived from CD73 safeguards tissues from ischemia (hypoxia) and inflammation. It promotes vasodilation, reduces tissue damage during inflammation, and improves blood flow to injured areas.
KMD Bioscience is an innovative biotechnology company dedicated to providing high-quality NT5E/CD73 proteins, NT5E/CD73 antibodies and other high-quality target products to research institutions, universities and companies. Adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality NT5E/CD73 related products and promoting the continuous innovation and development in the field of biotechnology.
The featured target NT5E/CD73 protein products launched by KMD Bioscience:
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CAT# |
Product Name |
Species |
Host |
Size |
Inquiry |
|
KMPH2432 |
Human |
HEK293 Cells |
20ug, 100ug |
||
|
MOP1213 |
Mouse |
HEK293 Cells |
10ug, 20ug |
||
|
KMPH5505 |
Human |
HEK293 Cells |
20ug, 100ug |
||
|
KMPH5681 |
Human |
HEK293 Cells |
20ug, 100ug |
||
|
KMH240 |
Human |
Mammalian cells |
50ug, 100ug |
The featured target NT5E/CD73 antibody product launched by KMD Bioscience:
|
CAT# |
Product Name |
Species |
Host |
Appliance |
Size |
Inquiry |
|
PA12693 |
Human |
Rabbit |
WB, IHC, IF |
50ul, 100ul |
Other advantageous products from KMD Bioscience:
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com