KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
CD357/GITR (Gene ID:8784) is a member of the tumor necrosis factor receptor (TNFR) superfamily, initially discovered in the late 1990s. It is expressed predominantly a variety of immune cells, including T cells, B cells, dendritic cells, and natural killer (NK) cells. CD357/GITR is notable for its involvement in immune regulation and its potential as an immunotherapeutic target. CD357/GITR acts as a co-stimulatory receptor on T cells. Upon binding to its ligand GITRL (GITR ligand or TNFSF18), CD357/GITR enhances T cell activation and proliferation. GITRL is normally expressed on APCs. This co-stimulation contributes to the expansion of effector T cell populations. CD357/GITR is critical for the function of regulatory T cells (Tregs), which are a specialized subset of T cells responsible for suppressing suppressing immune responses and maintain immune tolerance. The signaling pathway mediated by CD357/GITR disrupts Treg suppression, leading to activation of effector T cells and enhanced immune responses. CD357/ GITR has received attention as a target for cancer immunotherapy. Activation of agonistic antibodies or ligands targeting CD357/GITR on T cells can enhance anti-tumor immune responses. The potential of combination therapies involving CD357/GITR agonists in cancer treatment is currently being investigated in preclinical and clinical studies.
KMD Bioscience is an innovative biotechnology company dedicated to providing high-quality CD357/GITR proteins, CD357/GITR antibodies and other high-quality target products to research institutions, universities and companies. Adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality CD357/GITR related products and promoting the continuous innovation and development of the biotechnology field.
The featured target CD357/GITR protein products launched by KMD Bioscience:
|
CAT# |
Products Name |
Specise |
Host |
Size |
Inquiry |
|
KMPH4362 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH4363 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
PR257 |
Rat |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5843 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5844 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5845 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5846 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5847 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5848 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMH489 |
Human |
Mammalian cells |
50ug, 100ug |
||
|
MOP2168 |
Mouse |
Mammalian cells |
50ug, 100ug |
||
|
KMH1829 |
Human |
Mammalian cells |
50ug, 100ug |
The featured target CD357/GITR antibody products launched by KMD Bioscience:
|
CAT# |
Products Name |
Specise |
Host |
Appliance |
Size |
Inquiry |
|
PA9273 |
Human |
Rabbit |
WB |
50ul, 100ul |
Other advantageous products from KMD Bioscience:
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com