KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
CD279 (Gene ID:5133) was discovered in the late 1990s as a member of the CD28/CTLA-4 family of immune checkpoint receptors. In contrast to CD28, which provides co-stimulatory signals for T-cell activation, CD279 transmits inhibitory signals upon binding to its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). It is expressed in various cell types, including cancer cells and antigen-presenting cells (APCs). This interaction is essential for maintaining immune homeostasis and preventing excessive immune responses. The main functions of CD279 are as follows:
1. Immune checkpoint regulation: CD279 is an important regulator of the immune response. When bound to its ligand, CD279 transmits inhibitory signals that suppress T cell activation and proliferation, preventing excessive immune responses. This mechanism is essential to avoid autoimmunity and immune-mediated tissue damage.
2. T-cell exhaustion: CD279 is closely linked to T-cell exhaustion, a state of dysfunction commonly observed in chronic infections and cancers. Persistent CD279 signaling can impair the effector function of T cell, leading to ineffective immune responses against persistent pathogens or tumors.
3. Immune evasion in cancer: The PD-1 pathway is frequently exploited by cancer cells to evade immune surveillance. Through the upregulation of PD-L1 expression, cancer cells can effectively suppress the cytotoxicity of tumor-specific T cells, thereby permitting tumor growth and immune escape.
4. Therapeutic targets: CD279 has emerged as an important target for cancer immunotherapy. Monoclonal antibodies targeting CD279 or its ligands have been developed to block inhibitory signaling and enhance anti-tumor immune responses. Remarkable has been achieved in the treatment of various cancers using drugs such as pembrolizumab and nivolumab.
5. Autoimmune Diseases: Dysregulation of CD279 signaling can lead to autoimmune diseases, as excessive suppression of T-cell responses may disrupt immune tolerance. Therefore, a comprehensive understanding and regulating CD279 signaling are critical for the development of therapies for autoimmune diseases.
KMD Bioscience is an innovative biotechnology company dedicated to providing high-quality PDCD1/CD279 proteins, PDCD1/CD279 antibodies, and other high-quality target products to research institutions, universities and companies. Adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality PDCD1/CD279 related products and promoting the continuous innovation and development in the field of biotechnology.
The featured target PDCD1/CD279 protein products launched by KMD Bioscience:
|
CAT# |
Products Name |
Species |
Host |
Size |
Inquiry |
|
KMPH1429 |
Human |
HEK293 Cells |
100ug, 200ug |
||
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KMPH1430 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH1533 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH1534 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
MOP1135 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
|
MOP1136 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
|
MOP1691 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
|
MOP1692 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
|
PM296 |
Cynomolgus |
HEK293 Cells |
100ug, 200ug |
||
|
PM297 |
Cynomolgus |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5864 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5865 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5866 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5867 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5868 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5869 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5870 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5871 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5872 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5873 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5874 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5875 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5876 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5877 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5878 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5879 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5880 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5893 |
Human |
HEK293 Cells |
100ug, 200ug |
The featured target PDCD1/CD279 antibody products launched by KMD Bioscience:
|
CAT# |
Products Name |
Species |
Host |
Appliance |
Size |
Inquiry |
|
PA5704 |
Human |
Rabbit |
WB, IHC, IF |
50ul, 100ul |
||
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PA9042 |
Human |
Rabbit |
WB, IF |
50ul, 100ul |
||
|
PA10709 |
Human |
Rabbit |
WB, IHC |
50ul, 100ul |
||
|
PA11371 |
Human |
Rabbit |
WB |
50ul, 100ul |
||
|
PA13127 |
Human |
Rabbit |
IHC |
50ul, 100ul |
Other advantageous products from KMD Bioscience:
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com