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2023-08-24 Hits(378)
Laboratory mice kept in specific-pathogen-free (SPF) conditions are routinely used to dissect the immune system, but they lack the microbial exposures that normally shape the immune system. 'Rewilding' systems, which expose mice to environmental microbes while preventing pathogenic infections, are being developed to address this issue and the immune systems of rewilded mice more closely resemble those of adult humans. The authors of this study previously reported that rewilded mice show a notable expansion of granulocytes and they could mimic this effect by colonizing the gut of laboratory mice with the commensal fungus Candida albicans. Here, they show that C. albicans provides tonic signaling that supports granulopoiesis by increasing the number and frequency of multipotent progenitors in the bone marrow. The C. albicans hypha-associated factor candidalysin was shown to be necessary for this effect and colonization with C. albicans enhanced mouse survival during blood infection with Staphylococcus aureus. Granulocytes normally comprise 50–70% of blood leukocytes in humans but only 5–10% in laboratory mice, so fungal colonization of these mice may improve their usefulness for translational work.
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