CLASH:Large-scale Engineering System for the Discovery of Better CAR T Cells

2023-08-29 Hits(320)

Adoptive immune cell therapy has been effective in treating haematological cancers. However, some patients experience disease relapse, which may be attributed to insufficient persistence of T cells. In addition, adoptive therapy using chimeric antigen receptor (CAR) T cells is more limited in solid tumours owing to the infiltration barriers and immunosuppressive microenvironment of these tumours. To address these challenges, high-throughput screening of modified T cells is the most efficient way to identify variant.

 

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