KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
| Catalog Number | KMH517 |
|---|---|
| Product Name | Recombinant Human IDO/IDO1 Protein, His Tag |
| Product Description | Recombinant Human IDO/IDO1 Protein, His Tag (KMH517) contains the human IDO1(Ala2-Gly403) was fused with the N-terminal His Tag and expressed in E. coli. |
| Molecular Name | IDO1 |
| Uniprot ID | P14902 |
| Alias | IDO, INDO, IDO 1, indoleamine 2, 3 dioxygenase 1 |
| Protein Family | Immune checkpoint |
| Size | 50ug, 100ug |
| Species | Human |
| Host | E. coli |
| Molecular Weight | 44.33 kDa |
| Purity | ≥90% as determined by SDS-PAGE |
| Endotoxin | Please contact our customer service for more information. |
| Cross-Reactivity | No cross-reactivity with other antigens or proteins. |
| Buffer | PBS |
| Purification | Affinity Purification |
| Background | Indoleamine 2, 3-dioxygenase(IDO) is a hemecontaining intracellular dioxygenase catalyzing the degradation of the essential amino acid L-tryptophan toN-formylkynurenine. This degradation is the first and ratelimiting step of the L-kynurenine pathway. IDO is widely expressed in dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumor cells. In immune cells, its expression is mainly induced by cytokines such as IFN-γ, IFN-α, IFN-β, and IL-1. IDO has an antimicrobial function due to its decreasing the availability of the essential amino acid tryptophan in inflammatory environments.Recent studies have demonstrated that IDO induces immunosuppression during infection, pregnancy, transplantation, autoimmunity, and neoplasia. |
| Storage | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com
