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| Catalog Number | KMP2253 |
|---|---|
| Product Name | Human Biotinylated FGL1 Protein, Avi Tag, His Tag |
| Product Description | The Human Biotinylated FGL1 Protein(KMP2253) is produced in HEK293 Cells and the target gene encoding Leu23-Ile312 is expressed with a AVI, 6His tag at the C-terminus. |
| Molecular Weight | 34.84 kDa |
| Alias | Fibrinogen-like protein 1, FGL1 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purification | Affinity purification |
| Purity | >90% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | 20mM Tris, 300mM NaCl, 10% Glycerol, 2mM EDTA, pH8.0 |
| Uniprot | Q08830 |
| SDS-PAGE |  |
| Function | Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967). |
| Background | Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
| References | 1.Biochim. Biophys. Acta 1520:45-53 (2001) 2.Gut 59:817-826 (2010) 3.Cell 0:0-0 (2018) |
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