KMD Bioscience Co., Ltd.
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| Catalog Number | KMP2374 |
|---|---|
| Product Name | Mouse CD28 Protein, Fc Tag, His Tag |
| Product Description | The Mouse CD28 Protein(KMP2374) is produced in HEK293 Cells and the target gene encoding Asn20-Lys149 is expressed with a Fc, 6His tag at the C-terminus. |
| Molecular Weight | 15.88 kDa |
| Alias | CD28 molecule, Tp44 |
| Species | Mouse |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purification | Affinity purification |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | 20mM PB, 150mM NaCl, pH7.4 |
| Uniprot | P31041 |
| SDS-PAGE |  |
| Function | Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. |
| Background | T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals, which are required for their activation. It is the receptor for CD80 and CD86. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells(APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. It involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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Email：info@kmdbioscience.com
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