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| Catalog Number | KMP2397 |
|---|---|
| Product Name | Human CD276 Protein, His Tag |
| Product Description | The Human CD276 Protein(KMP2397) is produced in HEK293 Cells and the target gene encoding Leu29-Thr461 is expressed with a 6His tag at the C-terminus. |
| Molecular Weight | 47.35 kDa |
| Alias | CD276 antigen, CD276, B7 homolog 3 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purification | Affinity purification |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Uniprot | Q5ZPR3 |
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| Background | CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
| References | 1.Nat. Immunol. 2:269-274 (2001) 2.Genomics 82:365-377 (2003) 3.J. Immunol. 172:2352-2359 (2004) 4.Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645 (2004) 5.Eur. J. Immunol. 35:428-438 (2005) 6.Am. J. Respir. Cell Mol. Biol. 33:280-289 (2005) |
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