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Catalog Number | KMP2428 |
---|---|
Product Name | Human CD223 Protein, Fc Tag |
Product Description | The Human CD233 Protein(KMP2428) is produced in HEK293 Cells and the target gene encoding Leu23-Leu450 is expressed with a Fc tag at the C-terminus. |
Molecular Weight | 46.19 kDa |
Alias | Lymphocyte activation gene 3 protein, LAG3 |
Species | Human |
Host | HEK293 Cells |
Size | 50ug, 100ug, 200ug |
Purification | Affinity purification |
Purity | >95% as determined by SDS-PAGE |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Buffer | PBS, pH7.4 |
SDS-PAGE | |
Background | Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin(Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4. |
Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Note | This product is for research use only. |