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Human CD223 Protein, Fc Tag

Product Information
Catalog Number KMP2428
Product Name Human CD223 Protein, Fc Tag
Product Description The Human CD233 Protein(KMP2428) is produced in HEK293 Cells and the target gene encoding Leu23-Leu450 is expressed with a Fc tag at the C-terminus.
Molecular Weight 46.19 kDa
Alias Lymphocyte activation gene 3 protein, LAG3
Species Human
Host HEK293 Cells
Size 50ug, 100ug, 200ug
Purification Affinity purification
Purity >95% as determined by SDS-PAGE
Endotoxin <1.0 EU/ug determined by the LAL method
Buffer PBS, pH7.4
SDS-PAGE
Background Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin(Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
Storage Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Note This product is for research use only.