KMD Bioscience Co., Ltd.
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Email：info@kmdbioscience.com
| Catalog Number | KMP2676 |
|---|---|
| Product Name | Human BCA-1 Protein |
| Product Description | The Human BCA-1 Protein(KMP2676) is produced in E. coli. The target gene encoding the human CXCL13 (NP_006410.1) (Val23-Arg94) is expressed with an initial Met. |
| Molecular Name | BCA-1 |
| Alias | Human BCA-1 Protein, BCA-1 |
| Molecular Weight | 8.8 kDa |
| Species | Human |
| Size | 50ug, 100ug, 200ug |
| Host | E. coli |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | 50mM Tris, 0.5M NaCl, pH7.5 |
| Purification | Affinity purification |
| Background | The chemokine CXCL13, also known as BCA-1 (B-cell-attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), which belongs to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. It involves in B-cell compartmental homing within secondary lymphoid organs and recently implicated in the pathogenesis of inflammatory and malignant lymphocyte-mediated diseases. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). In T-lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T-cell. CXCL13 expression may also provide an additional useful tool for the diagnosis of Angioimmunoblastic T-cell lymphoma (AITL). |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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Email：info@kmdbioscience.com
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