KMD Bioscience Co., Ltd.
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| Catalog Number | KMP3648 |
|---|---|
| Product Name | Cynomolgus BCA-1 Protein, His Tag |
| Product Description | The Cynomolgus BCA-1 Protein(KMP3648) is produced in E. coli. A DNA sequence encoding the mature form of Cynomolgus (Macaca fascicularis) CXCL13 (Val 23-Pro 109) is expressed, with an N-terminal polyhistidine tag. |
| Molecular Name | BCA-1 |
| Alias | BCA-1 Protein, Cynomolgus BCA-1 Protein, His Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Cynomolgus |
| Host | E. coli |
| Purity | >90% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | 10mM Tris, 250mM NaCl, pH8.0 |
| Purification | Affinity purification |
| Molecular Weight | 12.4 kDa |
| Background | The chemokine CXCL13, also known as BCA-1 (B-cell-attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), which belongs to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. It involves in B-cell compartmental homing within secondary lymphoid organs and recently implicated in the pathogenesis of inflammatory and malignant lymphocyte-mediated diseases. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). In T-lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T-cell. CXCL13 expression may also provide an additional useful tool for the diagnosis of Angioimmunoblastic T-cell lymphoma (AITL). |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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