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| Catalog Number | KMP2707 |
|---|---|
| Product Name | Human B7-1 Protein, His Tag |
| Product Description | The Human B7-1 Protein(KMP2707) is produced in HEK293 Cells. The target gene encoding the extracellular domain (Met1-Asn242) of human B7-1 (NP_005182.1) precursor is fused with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro. |
| Molecular Name | B7-1 |
| Alias | Human B7-1 Protein, His Tag, B7-1 |
| Molecular Weight | 25.4 kDa |
| Species | Human |
| Size | 50ug, 100ug, 200ug |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS |
| Purification | Affinity purification |
| Background | The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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