Service Line:+1-315-239-3085
Address:FL-4, Building A5, International Enterprise Community, Tianjin, China
Email:info@kmdbioscience.com
Catalog Number | KMP4184 |
---|---|
Product Name | Rat B7-1 Protein, His Tag |
Product Description | The Rat B7-1 Protein(KMP4184) is produced in HEK293 Cells. A DNA sequence encoding the Rat CD80 (AAB60503.1) (Met1-Gln248) is expressed with a polyhistidine tag at the C-terminus. |
Molecular Name | B7-1 |
Alias | B7-1 Protein, Rat B7-1 Protein, His Tag |
Size | 50ug, 100ug, 200ug |
Species | Rat |
Host | HEK293 Cells |
Purity | >95% as determined by SDS-PAGE |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Buffer | PBS, pH7.4 |
Purification | Affinity purification |
Molecular Weight | 25.38 kDa |
Background | The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. |
Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Note | This product is for research use only. |