KMD Bioscience Co., Ltd.
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| Catalog Number | KMP3704 |
|---|---|
| Product Name | Cynomolgus TIGIT Protein, hFc Tag |
| Product Description | The Cynomolgus TIGIT Protein(KMP3704) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus TIGIT (XP_015300911.1) (Met1-Pro209) is expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | TIGIT |
| Alias | TIGIT Protein, Cynomolgus TIGIT Protein, hFc Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Cynomolgus |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Molecular Weight | 47.2 kDa |
| Background | TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-1 and diminished the production of IL-12p4. Also, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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