KMD Bioscience Co., Ltd.
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| Catalog Number | KMP3764 |
|---|---|
| Product Name | Cynomolgus EpCAM Protein, hFc Tag |
| Product Description | The Cynomolgus EpCAM Protein(KMP3764) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus/Rhesus EPCAM [(Identical to the Rhesus EPCAM (NP_001035118.1)] (Met1-Lys265) is expressed with the Fc region of human IgG1 at the C-terminus. Cynomolgus and Rhesus EPCAM sequences are identical. |
| Molecular Name | EpCAM |
| Alias | EpCAM Protein, Cynomolgus EpCAM Protein, hFc Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Cynomolgus |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Molecular Weight | 54.1 kDa |
| Background | Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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Email：info@kmdbioscience.com
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